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If small molecules can match the efficacy and tolerability of GLP-1 peptides, we could manufacture with the small-molecule playbook: robust synthesis routes, cheaper inputs, wellunderstood solid-form control, and site-to-site transfer techniques that have been proven over decades

Fibre supplementation has more consistent, though modest, evidence

Lyle has been writing about fitness, nutrition, dieting, and female physiology for decades, and in this episode we unpack the physiological, behavioral, and practical reasons why fat loss can be more difficult for women

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