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Interestingly, the enzymatic machinery required for the local processing of GLP-1 was also detected and appeared to be sensitive to diet-induced obesity: mRNAs encoding prohormone-convertase 1/3 ( Pcsk1 ) and dipeptidyl peptidase-4 ( Dpp4 ) were identified and significantly increased in WD mice compared to RD mice (Fig

Finally, in the MASLD clinical trial, liver fat reduction was closely related to improvements in cardiometabolic biomarkers, including body weight, insulin sensitivity, and triglyceride levels [58]

Sattar, D.K

Understanding the TRIUMPH-1 results is vital for evaluating Retatrutide's future role in medical weight loss