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As noted, the difference in food intake between the TZP and TZP+FcLep groups gradually diminished during the final week of dosing, suggesting a compensatory phase

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Abbreviations CNRC: Childrens Nutrition Research Center FFM: Fat-free mass GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide-1 GPR: Glucose production rate HISI: Hepatic insulin sensitivity index IGI: Insulinogenic index iGLP-1: Intact GLP-1 MIGHTY: Metformin Influences Gut Hormones in Youth NGT: Normal glucose tolerance NIH: National Institutes of Health PYY: Peptide YY R a : Rate of appearance WBISI: Whole-body insulin sensitivity index References Zeitler P, Hirst K, Pyle L et al (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes

While these injections have proven beneficial in managing type 2 diabetes and reducing HbA1c levels, they also contribute to cardiovascular health