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Losing weight is not something your body wants you to do, its more or less an evolutionary fact that it is very much in support of you retaining excess calories to use as energy later when you are getting chased by a tiger or something

Clinicians, therefore, try smaller increments to preserve adherence and allow muscle-preserving lifestyle work to continue alongside medication

doi:10.1001/jamainternmed.2025.1133 "How Fast Do GLP-1 Drugs Suppress Appetite?" Cleveland Clinic , Cleveland Clinic Health Essentials Staff, 28 Aug

They can also help determine if a dietary supplement is needed to help meet your nutrient needs