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113 N-acetylcysteine N-acetylcysteine (NAC), a free radical-quenching compound made from the sulfur-containing amino acid cysteine, has been shown to reduce inflammation and oxidative stress, stabilize proteins and DNA, promote mitochondrial resilience, support antiviral immune activity, and promote vascular health

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Similarly, targeting NRF2 to upregulate phosphorylase kinase catalytic subunit 2 promotes ferritinophagy and mitochondrial stress-dependent ferroptosis, increasing radiosensitivity (123)