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Human bone marrow mesenchymal stem cell-derived extracellular vesicles (hBMSC-EVs) have shown promise in counteracting ROS-induced ALP overactivation ( In vitro and in vivo studies demonstrate that hBMSC-EVs reduce ROS, enhance antioxidant defenses (e.g., SOD1), and restore SIRT1/PGC-1 signaling
[DOI] [PubMed] [Google Scholar] [38].Chen Q, Camara AK, Stowe DF, Hoppel CL, Lesnefsky EJ
SAG administration significantly reduced the collagen deposition (Figure 7D,E), hydroxyproline content (Figure 7F) and -SMA (Figure 7G) and TGF- (Figure 7H) levels, whereas it increased IL10 expression (Figure 7I) in the liver tissue
[PubMed] [Google Scholar] 48.Suzuki N, Uebaba K, Kohama T, Ohno S, Moniwa N, Kanayama N, et al
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