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found that in colon cancer, Gln deprivation stimulates p53 activation and promotes the expression of the aspartate/glutamate transporter SLC1A3, thereby promoting glutamate, Gln and nucleotide synthesis, maintaining electron transport chain and tricarboxylic acid cycle activity

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The disease affects approximately 10% of the global population, with prevalence varying across regions due to differences in age, demographics, socioeconomic status, and access to healthcare (Rovin et al., 2024) and studies have consistently demonstrated a rising prevalence in both developed and developing countries

Novo Nordisk), and glycaemia (mg/dL) was monitored following the same protocol as was used for glucose tolerance tests