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Alternatives in Class At a glance Brand Vyvanse (30-day supply) / $350 to $450 cash price Generic lisdexamfetamine (30-day supply) / $30 to $80 cash price (since August 2023) Generic mixed amphetamine salts XR / $15 to $50 per month Generic methylphenidate ER / $20 to $45 per month FDA-approved indications / ADHD (ages 6+) and binge eating disorder (adults) Duration of action / 12 to 13 hours in controlled trials DEA schedule / Schedule II controlled substance Prodrug conversion / Lisdexamfetamine is cleaved to d-amphetamine in red blood cells Patent expiration / August 2023 (first generics launched) Insurance tier / Tier 2 to 3 for generics

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