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However, beware that if you have a concurrent COMT mutation, it might be best to not take too much methyl B12, but a combo of hydroxy or adeno B12
The Philippines FDA has issued a formal warning against high-dose unsupervised cosmetic IV glutathione, and a 2025 case series in the International Journal of Dermatology documented liver function abnormalities in approximately half of high-dose IV-treated participants in unmonitored settings, which is precisely why the DermaVue protocol restricts dosing to the 400 to 1200 mg clinical range and enforces hepatic monitoring
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A deficiency in this nutrient can lead to bone health issues and compromised immune responses
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