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Common Side Effects of Semaglutide Semaglutide, like any medication, can cause side effects

Detailed records of solution preparation, including which calculator was used and what inputs were entered

It is the first medication to meaningfully address both sides of the energy balance equation: | Medication | What It Reduces | What It Burns | Max Weight Loss | |-----------|----------------|---------------|-----------------| | Semaglutide | Appetite (GLP-1) | -- | ~15-17% | | Tirzepatide | Appetite (GIP + GLP-1) | Minimal | ~20-22% | | **Retatrutide** | **Appetite (GIP + GLP-1)** | **Calories (Glucagon)** | **~24%** | That additional glucagon column is why retatrutide achieved more weight loss in less time than either competitor

Am J Physiol Liver Physiol 293:G211G221