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Recently, CVB3 was observed to infect all cell types present in isolated primary human islets, including endocrine, exocrine, vascular, and immune cells, and elicit a cell-type-specific transcriptional response using single-cell RNA sequencing (149)
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Specifically, they observed elevations in: Acetylcholine: Critical for memory formation and cognitive processing Dopamine: Essential for motivation, focus, and reward GABA: The brain's primary inhibitory neurotransmitter These changes in neurotransmitter levels were consistent across both young and aged animals, though young animals generally exhibited higher baseline levels of all neurotransmitters compared to their older counterparts
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