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The use of methotrexate may additionally invalidate diagnostic assays for folic acid and vitamin B12

111 A similar study involving individuals with metabolic syndrome found curcumin had a beneficial effect on lipid parameters (decreased LDL and increased HDL)

Moreover, NADPH binding induced a dramatic conformational change in the NLL region of Pa DHDPR, with His35 and Lys36 in this region interacting with the adenine phosphate of NADPH and critical for nucleotide binding