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The abdomen provides reliable subcutaneous tissue and easy self-access

For people with CKD, creatinine is not excreted efficiently, leading to low creatinine levels in the urine and high creatinine levels in the blood

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They promote lipid, protein, and DNA oxidation, forming cytotoxic products such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise mitochondrial DNA and disrupt electron transport, especially at complexes I and III (Wang et al., 2024)