hypothyroidism and tirzepatide & Hypothyroidism: Safety, Biomarkers & Thyroid Mon... – PlexusDx Mounjaro and Hypothyroidism: Hashimoto's Safety

Tier 1: Pure GLP-1, injectable, FDA-approved Exenatide (Byetta, Bydureon) Liraglutide (Victoza, Saxenda) Lixisenatide (Adlyxin) Dulaglutide (Trulicity) Semaglutide (Ozempic, Wegovy) Efpeglenatide (Eperzan) Tier 2: Pure GLP-1, oral, FDA-approved Semaglutide (Rybelsus) Orforglipron (Orfoglip) Tier 3: Dual or triple agonist, FDA-approved Tirzepatide (Mounjaro, Zepbound) Retatrutide (Retara) Tier 4: Compounded (not FDA-approved) Compounded semaglutide Compounded tirzepatide Compounded semaglutide + B12 Compounded tirzepatide + B12 The tier system reflects regulatory status, not efficacy

APCs present thyroid autoantigens to T cells via HLA class II molecules, providing the first activation signal through the T-cell receptor

doi: 10.1136/bmj.g5226

RAI works by getting into overactive thyroid cells and destroying enough thyroid tissue to lower thyroid hormone levels [16, 4]