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Among 21,822 people of European ancestry, we required participants to have complete data needed to construct the target phenotype and GWAS covariates (that is, data available for pre-treatment weight, post-treatment weight, drug type, dosage, time on treatment and factors such as age, sex and height), resulting in 18,488 participants

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The pre-therapy mean vitamin B12 level in the oral and IV arms was 157 66 picogram/ml and 173 55 picogram/ml (p=0.59 ) respectively and the post-therapy mean vitamin B12 level was 870 348 picogram/ml and 1273 511 picogram/ml (p=0.02 ) respectively [Figure 1]