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This downregulation facilitated the dissociation of STIM1 from STING, thereby activating the non-canonical STING signaling pathway and enhancing autophagy in cortical neurons

It also identified dosing errors as a specific concern, including patients measuring and self-administering incorrect doses and clinicians miscalculating doses, and reports that may relate to prescribing beyond approved labeling more product per dose, more frequent dosing, or faster escalation