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These concerns stem from early animal studies and human reports suggesting that semaglutide drugs may stimulate abnormal cell growth in the thyroid or pancreas

These findings highlight the potential of GLP-1 drugs beyond weight loss, suggesting they can play an important role in treating substance use disorders by influencing the brains reward pathways

Interestingly, the neural circuits responsible for the metabolic effects of GLP-1R agonism may be distinct from those mediating nausea or malaise (Huang et al., 2024), suggesting that future therapies could be tailored to preserve metabolic benefits while minimizing gastrointestinal side effects

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