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Increased perfusion occurs within 5-10 minutes, via insulin action on three different receptors in the endothelium, including insulin receptors, IGF-I receptors, and the insulin/IGF-I hybrid receptors, and this occurs well before the increase in insulin-stimulated glucose disposal (~ 20-30 minutes) in muscle
Taken together, these findings lead us to conclude that GLP-1R not only plays an important role in the treatment of DM and AD but also may serve as a bridge between these two diseases
This method is also recognized for the treatment of obesity in Europe and the US
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