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In other words, after decades of advising HF patients to avoid drinking to prevent fluid buildup, we now have to explain to selected patients who show no signs of fluid retention that they risk dehydration due to their diuretic (or diuretic-like) therapy beyond LDs (MRAs, SGLT2I, sacubitril)

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The medication should be taken first thing upon waking, at least 30 minutes before consuming any food, beverages (other than plain water), or other oral medications

Long-term safety data from real-world use and extended trials shows that most patients tolerate semaglutide well beyond the initial 12-month period