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There was a tendency toward higher t 1/2 with increasing hepatic impairment ranging from 174 h (range 144204 h) in the group with normal hepatic function to 199 h (range 184214 h) in the group with severe hepatic impairment

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A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression

pero tambin existen alimentos que en su composicin aaden este compuesto, como pueden ser las barritas energticas u otros productos enfocados al mbito deportivo