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Common side effects Nausea Diarrhea or constipation Vomiting Abdominal pain Decreased appetite Serious risks Pancreatitis (inflammation of the pancreas) Gallbladder problems Low blood sugar, especially with other diabetes medicines Kidney problems related to dehydration Serious allergic reactions Do not use if you have Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known serious allergy to tirzepatide Pregnancy or breastfeeding How it compares Frequently asked questions What is compounded tirzepatide