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Concurrently, it is imperative to disentangle the concrete regulation on functional subgroups of the gut microbiota induced by metabolites from articular ferroptosis (for example, ROS and LPO) (such as probiotic genus composition, abundance of populations such as those of Lactobacillus and the Bacteroidetes/ Firmicutes ratio) and gut structural mucosal barrier integrity (for example, the expression of tight junction proteins, such as occludin and claudin)

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Depression increases the risk of conversion from normal aging to mild cognitive impairment (MCI), and from MCI to Alzheimers Disease (AD) [8, 10,11,12,13], making LLD a potential target for dementia prevention [14, 15]