Other effects of melanotan II, mostly regarded as adverse effects, include flushing, nausea, vomiting, stretching, yawning, and loss of appetite (the last via activation of MC4)
This can make some people feel full or sick to their stomach

Abbreviations AhR : aryl hydrocarbon receptor, ALDH1 : aldehyde dehydrogenase 1, ARHI : aplasia rag homolog member 1, atRA : all-trans retinoic acid, BCL2 : B-cell lymphoma 2, BMP-7 : bone morphogenetic protein 7, C4orf47 : chromosome 4 open reading frame 47, C1orf116 : chromosome 1 open reading frame 116, CNV : copy number variation, DNMT : DNA methyltransferase, EMT : epithelial-to-mesenchymal transition, ERK : extracellular signal-regulated kinase, ER+ : estrogen receptor positive, EZH1/2 : enhancer of zeste homolog 1/2, FBXW7 : F-box and WD repeat domain containing 7, FGFR : fibroblast growth factor receptor, HDAC : histone deacetylase, HNSCC : head and neck squamous cell carcinoma, IDO : indolamine 2,3-dioxygenase IFN- : interferon beta, Kyn : kynurenine, LOXL2 : lysyl oxidase like 2, LPS : lipopolysaccharide, LSD1 : lysine-specific demethylase 1, miRNAs : micro ribonucleotide acids, MMP-9 : matrix metalloproteinase-9, NETs : neutrophil extracellular traps, NE : neutrophil elastase, NK cell : natural killer cell, NRF2 : nuclear factor-like 2, NSCLC : non-small-cell lung cancer, Pfkfb3 : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, PMN : polymorphonuclear neutrophils, PMN-MDSC : polymorphonuclear myeloid-derived suppressor cell, PPAR : peroxisome proliferator-activated receptor gamma, STAT3 : signal transducer and activator of transcription 3, TBK1 : TANK binding kinase 1, TFF3 : Trefoil factor 3 Acknowledgments None

2023;13(2): e200127