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The FDA has approved glutathione as an antioxidant, but not for skin-whitening purposes

This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome

They are required to follow cGMP, which is substantially more rigorous than the 503A framework though still not identical to the full apparatus that governs an approved finished drug