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The 500 mcg per-capsule dose mirrors the per-day intake used in the bulk of rodent oral studies, and the gastric origin of the parent molecule provides a biological rationale for stability through the GI tract a feature documented across multiple oral-administration preclinical models

In addition, exendin-4 at 0.1100 nM concentrations for 2496 h increased GLP-1R activation, p53, p21, p38, cAMP, Bax/Bcl-2 ratio, and p38/MAPK activation

Retrospective case series of paediatric patients referred to national poisons centres also report a lower rate of liver injury and hepatotoxicity in children compared with adults following single acute overdose [52,53,54,55]