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Retatrutide improved fasting lipid profiles including triglycerides, very low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in clinical trials in people with T2D or obesity, while low-density lipoprotein cholesterol was reduced in people with obesity 12,13,28
These agents bind directly to GLP-1 receptors on pancreatic beta cells, triggering a cascade of physiological responses that improve glycemic control in patients with type 2 diabetes mellitus
Mechanistically, bone loss during weight reduction can be attributed to a combination of factors
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