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Neural activation and POMC expressions were observed in two different neuronal populations
With reduced total food intake, protein becomes the single most consequential macronutrient
Butyrate administered in pharmacological doses (5 mM) directly to ex vivo rat islets can increase GSIS (Wang et al., 2022), but this effect might potentially be due to mechanisms unrelated to its binding to FFARs, such as on chromatin remodelling (Priyadarshini et al., 2015), found that primary isolated wild-type mouse islets secrete 50% more insulin in a GSIS assay following co-stimulation with acetate and Exendin-4 compared to FFA2 KO islets
The strongest results in trials were seen after 6 months, 12 months and beyond
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