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Research suggests that Melanotan 2 functions as a non-selective melanocortin receptor agonist, with possible activity at MC1R, MC3R, MC4R, and MC5R

Interestingly, GFR remained increased even 14 days after cessation of rhIGF-1 therapy compared to placebo-treated controls, suggesting that rhIGF-1 resulted in renal hypertrophy, since the hemodynamic effects should have worn off within 14 days of cessation

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