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While Ser2 of oxyntomodulin and Ala8 of GLP-1 both interacted with TM7 residues, these interactions were stronger with oxyntomodulin due to a persistent hydrogen bond between Ser2 and E387 7.42 and transient hydrogen bonds and van der Waals contacts with K383 7.38 , D372 ECL3 and L384 7.39 (Supplementary Table 3)

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Lam CSP, Ramasundarahettige C, Branch KRH et al (2022) Efpeglenatide and clinical outcomes with and without concomitant sodium-glucose cotransporter-2 inhibition use in type 2 diabetes: exploratory analysis of the AMPLITUDE-O Trial

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