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[4] Why Vitamin B12 Can Cause Gastrointestinal Symptoms The mechanisms underlying gastrointestinal side effects from vitamin B12 supplementation are not fully established, but several factors may contribute to stomach discomfort in susceptible individuals
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100% IM) IM bioavailability: ~100% Tmax: 12-24 hours (SC), 6-12 hours (IM) Half-life: 29-36 hours (allows for 2-3x/week dosing) Renal clearance: primary Detection: urine/serum up to 7-14 days post-administration Applications, Mechanisms, and Extended Research 1
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