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SURPASS-CVOT is a phase 3 study enrolled approximately 13,000 patients at least 40 years of age and have a diagnosis of type 2 diabetes, confirmed atherosclerotic cardiovascular disease, HbA1c 7.0% to 10.5% and a body mass index (BMI) 25 kilograms per meter squared (kg/m 2 )

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This increased susceptibility is largely driven by frequent comorbidities such as chronic kidney disease (CKD) and type 2 diabetes (T2D), which contribute to fluid and electrolyte imbalances [10]

Patients should not stop semaglutide or change their dosing schedule without discussing symptoms with their prescribing clinician, as treatment plans should always be individualized