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Indeed, it has been suggested that agents capable of achieving an average weight reduction of about 15% in individuals with obesity represent a new generation of anti-obesity medications, as this level of weight loss is sufficient to combat or prevent a broader range of obesity-related complications (238)

The affinity profile is calibrated for triple balance: full agonist at GIPR, full agonist at GLP-1R, partial agonist at GCGR, preserving glycemia while exploiting glucagon thermogenic benefits

A 2018 study published in Diabetes Care compared multiple semaglutide doses and confirmed that weight loss is dose-dependent, even at lower doses

doi:10.1016/j.eclinm.2024.102689 Marso SP, et al