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Supplementary material The Supplementary material for this article can be found online at: Statements Author contributions MJ and LZ performed the literature search and wrote the manuscript

It also recovers more heat and requires less plant steam than a system that produces WFI hot

These diverse mechanisms underscore their potential as nontoxic adjuvants and therapeutic agents in future cancer treatment strategies (140)

Disease-anchored panels and how to act on them For disease-anchored panels, tailor the readouts to the biology and act on the map they provide: in cardiovascular/vascular beds, pair DHE-HPLC (to quantify O 2 ) with compartment-targeted HyPer for H 2 O 2 , then add F 2 -isoprostanes/3-nitrotyrosine and iron indices to distinguish NOX-driven endothelial dysfunction (O 2 ONOO lowering NO bioavailability) from mitochondrial bursts typical of ischemiareperfusion (Bkgaard Nielsen et al