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Conversion of calcidiol to its biologically active form, calcitriol, occurs through the activity of a specific 25-hydroxyvitamin D 3 1--hydroxylase (commonly just called 1--hydroxylase) present in the inner mitochondrial membrane of cells of the proximal convoluted tubules of the kidneys, and in several extrarenal sites such as in keratinocytes, macrophages, and placenta

Wick MR, Swanson PE, Rocamora A

In addition, the anti-inflammatory effect of glutathione helps relieve symptoms of inflammation-related conditions such as rheumatic diseases by reducing inflammation