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This leads to: Increased cAMP signaling Enhanced GH synthesis Increased pulsatile GH secretion Elevated downstream IGF-1 production Key characteristics of CJC-1295: Longer half-life than Sermorelin Sustained GH stimulation Increased endogenous IGF-1 production Often paired with growth hormone secretagogues such as Ipamorelin Many clinicians view CJC-1295 as an extended-duration version of the body's natural GHRH signal

Li X, Zhao Y, Gong S, Song T, Ge J, Li J, et al

[DOI] [PubMed] [Google Scholar] Hisadome K, Reimann F, Gribble FM, Trapp S, 2011

People taking the contraceptive pill are advised to use a back-up contraceptive for this reason if they vomit or have diarrhoea to avoid unintended pregnancy