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In almost half of these cases, male infertility is the main contributing factor ( One condition contributing to male infertility is varicocele when veins inside the scrotum enlarge due to free radical damage

Crucially, the hydrogel matrix protects insulin from gastric degradation while enabling pH-triggered release in intestinal alkaline environments, thereby mimicking the kinetics of physiological insulin secretion

Mitochondria functional assays demonstrated that HC modulated OCR in manner comparable to the mitochondrial uncoupler FCCP, supporting the hypothesis that HC acts as a functional mitochondrial uncoupler, similarly to other anthraquinones (Simeone, 2025)

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