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Mechanisms of Glycemic Control (The Pancreas) The primary mechanism for glycemic control involves the activation of GLP-1 receptors (GLP-1R) on pancreatic islet cells, initiating intracellular signaling cascades such as the cAMP/PKA and PI3K/Akt pathways (Figure 1)(Zheng et al., 2024)

Nausea - the most common side effect, reported more frequently at higher doses Diarrhoea Vomiting Constipation Abdominal pain or discomfort These side effects were generally mild to moderate in severity and were most common during the dose escalation period (the first 1216 weeks of treatment, when the dose is gradually increased)

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