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58 GLP-1RAs potentially may reduce the risk of AF onset and progression through direct and indirect effects on atrial remodelling, including a reduction in systemic inflammation, improvement of cardiomyocyte metabolism, autonomic nervous system modulation, regulation of intracellular Ca 2+ levels and prevention and possibly reversion of atrial fibrosis

Dulaglutide (brand name Trulicity) is a long-acting GLP-1 receptor agonist approved by the FDA in 2014 for adults with type 2 diabetes, and later for cardiovascular risk reduction in people with established or high cardiovascular risk

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