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In mammals, heterodimers of Brain and muscle ARNT-like protein-1 (BMAL1) and Circadian locomotor output cycles kaput (CLOCK) activate the transcription of the clock genes Period ( Per1-3 ) and Cryptochrome ( Cry1/2 ) throughout the day while their protein products, PER1-3 and CRY1/2, inhibit CLOCK:BMAL1 and consequently their own transcription during the night 1

Biochemistry 52 , 61456150 (2013)