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The cysteine residue in actin functions as a sensor for oxidative stress, resulting in a high level of sensitivity to ROS, RNS, and lipid peroxidation ( in vitro conditions, Cys 374 of actin has the highest reactivity, which leads to the formation of intramolecular disulfide bonds with Cys 285 or other actin molecules (Li et al., 2024)

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