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We find that those affected with stage 3 have the lowest overall levels of GPx3 and display non-overlapping 95% confidence intervals as compared to their unaffected siblings (95% CI Stage 3 [0.93 g/ml, 1.36 g/ml], 95% CI Unaffected [1.78 g/ml, 2.23 g/ml]) (Fig

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The damage landscape The damage landscape is dictated by both the ROS species and their location: in lipids, H 2 O 2 -initiated or OH-driven peroxidation generates reactive aldehydes that crosslink proteins and disrupt membrane architecture (Liu et al

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