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Two caveats matter when reading these numbers
The SELECT trial reflects the real world - older, diverse participants, and in usual care settings without lifestyle and behavioral support
Proper storage, often refrigerated and protected from light, is essential for preserving the compound's activity
Overall, we conclude that PC patients with low expression of VRK2 are sensitive to GSH-targeting therapy, while PC patients with high expression of VRK2 are re-sensitive to GSH-targeting therapy following VRK2 inhibition, indicating genetic aberrance of VRK2 expression stratifies the response of PC to metabolism-targeted therapies
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