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Novo Nordisk has asked the Food and Drug Administration to bar compounding pharmacies from making copies of its blockbuster weight loss drug semaglutide, arguing that the medication is too complex for the pharmacies to safely make

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one example is through the suppression of the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, which is an inflammatory complex containing three components, including NLRP3, caspase-1, and apoptosis-associated speck-like protein (ASC), resulting in the maturation and secretion of the proinflammatory cytokines Activation of the NLRP3 inflammasome plays an important role in high glucose-induced endothelial dysfunction in patients with type 2 diabetes mellitus and cardiovascular disorders