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Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation

All studies are conducted exclusively within non-clinical, in-vitro research environments designed for scientific investigation

Ingredients and dosages vary between clinics and compounding pharmacies with no standardisation

Body weight was recorded between 10 am and noon using a conventional weighing scale, and body composition was measured in the unanesthetized mouse by a quantitative magnetic resonance method using an EchoMRI 700 Analyzer