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Furthermore, a marked decline of IGF-I has also been related to a higher probability of hepatocarcinoma[217] and poorer prognosis in patients requiring liver surgery[218]

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Key Structural Differences# Head-to-Head: LEAD-6 Trial# The LEAD-6 trial (Buse et al., Lancet 2009) directly compared liraglutide 1.8 mg once daily with exenatide 10 mcg twice daily in 464 adults with type 2 diabetes inadequately controlled on metformin, sulfonylurea, or both over 26 weeks: Liraglutide was statistically superior for glycemic control and demonstrated better tolerability, with less persistent nausea and fewer hypoglycemia events