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The researchers believe that an increase in acute mental stress triggered the double transitions of graying because pigmentation returned when the stress subsided

They communicate with cells to trigger specific biological responsesfrom stimulating growth hormone release to promoting tissue repair

Additionally, controlled release reduces the likelihood of high concentrations of antioxidants being released at once, which could be damaging

The study found that daily supplementation with at least 400 IU of synthetic vitamin E (equivalent to 180 mg of RRR --tocopherol) resulted in a 4% increase in risk of death from any cause compared to placebo (125)