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[13] In 1890, Colonel Lilly fully turned over the day-to-day management of the business to J

Hyperammonemia is the cardinal detonator of an additional series of alterations that perpetuate and aggravate HE, such as oxidative stress, systemic inflammation, neurogliovascular unit dysfunction and microglia, increase in the permeability of the blood-brain barrier, astrocytic edema, and hyponatremia.17,18 Dysbiosis also plays a role in HE