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Thyroid axis changes Rapid weight loss consistently affects the hypothalamic-pituitary-thyroid axis

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These diseases may affect more people in todays aging society

Several metabolic adaptations make it challenging to sustain weight loss long-term, including hormonal changes, increased food noise, and the energy gap. Shifts in Hunger Hormones Hunger and satiety are partially driven by hormones released from the gut to the hypothalamus (a region of the forebrain)