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Pituitary gene expression levels of pro-inflammatory cytokines TNF- and LIF were higher than normal, but only in the acute phase of sepsis-induced critical illness (1-day sepsis group) and this by more than sevenfold and eightfold, respectively (Fig
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These treatments face several hurdles: They don't lower uric acid enough in many patients [1] People with other health problems, especially kidney disease, can't take them [1] Starting these medications can actually trigger more flares [1] Patients struggle to stick with long-term treatment [1] This is a big deal as it means that about 80% of patients taking pegloticase (a powerful uric acid-lowering drug) get flares in the first three months, even with preventive treatment [1]
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