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GLP-1R binds to GLP-1 to activate multiple intracellular signaling pathways, including the Cyclic Adenosine Monophosphate/Protein Kinase A (cAMP/PKA) signaling pathway, the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and the pathways associated with anti-inflammatory and antioxidant stress responses (for details, refer to Chapter III)

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Initially intended for those with Type 2 diabetes because of their effectiveness in balancing blood sugar levels and their impact on insulin sensitivity, doctors quickly realized their off-label potential for weight loss, leading to their widespread popularity today

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